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Iterative Type I Polyketide Synthases for Enediyne Core Biosynthesis

Enediyne natural products are extremely potent antitumor antibiotics with a remarkable core structure consisting of two acetylenic groups conjugated to a double bond within either a 9- or 10-membered ring. Biosynthesis of this fascinating scaffold is catalyzed in part by an unusual iterative type I...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Methods Enzymol
Prif Awduron: Horsman, Geoffrey P., Van Lanen, Steven G., Shen, Ben
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6312384/
https://ncbi.nlm.nih.gov/pubmed/19362637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0076-6879(09)04605-9
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