Abrogation of glucosidase I–mediated glycoprotein deglucosylation results in a sick phenotype in fission yeasts: Model for the human MOGS-CDG disorder

Glucosidase I (GI) removes the outermost glucose from protein-linked Glc(3)Man(9)GlcNAc(2) (G3M9) in the endoplasmic reticulum (ER). Individuals with congenital disorders of glycosylation MOGS-CDG bear mutations in the GI-encoding gene (gls1). Although GI absence has been reported to produce lethali...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Gallo, Giovanna L., Valko, Ayelén, Aramburu, Sofía I., Etchegaray, Emiliana, Völker, Christof, Parodi, Armando J., D'Alessio, Cecilia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311512/
https://ncbi.nlm.nih.gov/pubmed/30389790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004844
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