Translational switching of Cry1 protein expression confers reversible control of circadian behavior in arrhythmic Cry-deficient mice

The suprachiasmatic nucleus (SCN) is the principal circadian clock of mammals, coordinating daily rhythms of physiology and behavior. Circadian timing pivots around self-sustaining transcriptional–translational negative feedback loops (TTFLs), whereby CLOCK and BMAL1 drive the expression of the nega...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Maywood, Elizabeth S., Elliott, Thomas S., Patton, Andrew P., Krogager, Toke P., Chesham, Johanna E., Ernst, Russell J., Beránek, Václav, Brancaccio, Marco, Chin, Jason W., Hastings, Michael H.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310849/
https://ncbi.nlm.nih.gov/pubmed/30487216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811438115
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