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Site-specific cross-linking of proteins to DNA via a new bioorthogonal approach employing oxime ligation
DNA-protein cross-links (DPCs) are super-bulky DNA adducts induced by common chemotherapeutic agents, reactive oxygen species, and aldehydes, and also formed endogenously as part of epigenetic regulation. Despite their presence in most cells and tissues, the biological effects of DPCs are poorly und...
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| Udgivet i: | Chem Commun (Camb) |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6310614/ https://ncbi.nlm.nih.gov/pubmed/29851420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc01300d |
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