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Site-specific cross-linking of proteins to DNA via a new bioorthogonal approach employing oxime ligation

DNA-protein cross-links (DPCs) are super-bulky DNA adducts induced by common chemotherapeutic agents, reactive oxygen species, and aldehydes, and also formed endogenously as part of epigenetic regulation. Despite their presence in most cells and tissues, the biological effects of DPCs are poorly und...

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Detalhes bibliográficos
Publicado no:Chem Commun (Camb)
Main Authors: Pujari, Suresh S., Zhang, Yi, Shaofei, Ji, Distefano, Mark D., Tretyakova, Natalia Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310614/
https://ncbi.nlm.nih.gov/pubmed/29851420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc01300d
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