Deficiency of the AIM2–ASC Signal Uncovers the STING-Driven Overreactive Response of Type I IFN and Reciprocal Depression of Protective IFN-γ Immunity in Mycobacterial Infection

The nucleic acids of Mycobacterium tuberculosis can be detected by intracellular DNA sensors, such as cyclic GMP-AMP synthase and absent in melanoma 2 (AIM2), which results in the release of type I IFN and the proinflammatory cytokine IL-1β. However, whether cross-talk occurs between AIM2–IL-1β and...

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Publicado no:J Immunol
Main Authors: Yan, Shanshan, Shen, Hongbo, Lian, Qiaoshi, Jin, Wenlong, Zhang, Ronghua, Lin, Xuan, Gu, Wangpeng, Sun, Xiaoyu, Meng, Guangxun, Tian, Zhigang, Chen, Zheng W., Sun, Bing
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309432/
https://ncbi.nlm.nih.gov/pubmed/29255077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701177
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