GDF11 Decreases Pressure Overload Induced Hypertrophy, but Can Cause Severe Cachexia and Premature Death

RATIONALE: Possible beneficial effects of Growth Differentiation Factor 11 (GDF11) on the normal, diseased, and aging heart have been reported, including reversing aging induced hypertrophy. These effects have not been well validated. High levels of GDF11 have also been shown to cause cardiac and sk...

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Vydáno v:Circ Res
Hlavní autoři: Harper, Shavonn C, Johnson, Jaslyn, Borghetti, Giulia, Zhao, Huaqing, Wang, Tao, Wallner, Markus, Kubo, Hajime, Feldsott, Eric A, Yang, Yijun, Joo, Yunichel, Gou, Xinji, Sabri, Abdel Karim, Gupta, Priyanka, Myzithras, Maria, Khalil, Ashraf, Franti, Michael, Houser, Steven R
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309347/
https://ncbi.nlm.nih.gov/pubmed/30571461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.312955
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