Highly sensitive LC–MS/MS method to estimate doxepin and its metabolite nordoxepin in human plasma for a bioequivalence study

A selective, sensitive and rugged liquid chromatography–tandem mass spectrometry (LC–MS/MS) assay has been developed for the simultaneous determination of doxepin (Dox) and its pharmacologically active metabolite, nordoxepin (NDox) in human plasma. The analytes and their internal standards (IS) were...

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Publicat a:J Pharm Anal
Autors principals: Patel, Nirav P., Sanyal, Mallika, Sharma, Naveen, Patel, Dinesh S., Shrivastav, Pranav S., Patel, Bhavin N.
Format: Artigo
Idioma:Inglês
Publicat: Xi'an Jiaotong University 2018
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6308917/
https://ncbi.nlm.nih.gov/pubmed/30595944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpha.2017.06.004
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