Sensitive and rapid determination of amantadine without derivatization in human plasma by LC–MS/MS for a bioequivalence study

A highly sensitive, rapid and rugged liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) method was developed for reliable estimation of amantadine (AMD), an antiviral drug in human plasma. The analyte and internal standard (IS), amantadine-d6 (AMD-d6), were extracted from 200 µL plasma by...

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Bibliographische Detailangaben
Veröffentlicht in:J Pharm Anal
Hauptverfasser: Bhadoriya, Abhaysingh, Rathnam, Shivprakash, Dasandi, Bhavesh, Parmar, Dharmesh, Sanyal, Mallika, Shrivastav, Pranav S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Xi'an Jiaotong University 2018
Schlagworte:
Short Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004625/
https://ncbi.nlm.nih.gov/pubmed/29922490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpha.2017.10.003
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