Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation

Approximately, 30% of embryonic stem cells (ESCs) die after exiting self-renewal, but regulators of this process are not well known. Yap1 is a Hippo pathway transcriptional effector that plays numerous roles in development and cancer. However, its functions in ESC differentiation remain poorly chara...

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Vydáno v:eLife
Hlavní autoři: LeBlanc, Lucy, Lee, Bum-Kyu, Yu, Andy C, Kim, Mijeong, Kambhampati, Aparna V, Dupont, Shannon M, Seruggia, Davide, Ryu, Byoung U, Orkin, Stuart H, Kim, Jonghwan
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2018
Témata:
Stem Cells and Regenerative Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307859/
https://ncbi.nlm.nih.gov/pubmed/30561326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40167
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