CUDC‐907 blocks multiple pro‐survival signals and abrogates microenvironment protection in CLL

CUDC‐907, a dual PI3K/HDAC inhibitor, has been proposed to have therapeutic potential in hematopoietic malignancies. However, the molecular mechanisms of its effects in chronic lymphocytic leukaemia (CLL) remain elusive. We show that CLL cells are sensitive to CUDC‐907, even under conditions similar...

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Pubblicato in:J Cell Mol Med
Autori principali: Chen, Yixiang, Peubez, Chloé, Smith, Victoria, Xiong, Shiqiu, Kocsis‐Fodor, Gabriella, Kennedy, Ben, Wagner, Simon, Balotis, Constantine, Jayne, Sandrine, Dyer, Martin J. S., Macip, Salvador
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307843/
https://ncbi.nlm.nih.gov/pubmed/30353642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13935
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