The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/β-catenin signaling through a Dvl dependent mechanism

Van Gogh-like (Vangl) and Prickle (Pk) are core components of the non-canonical Wnt planar cell polarity pathway that controls epithelial polarity and cell migration. Studies in vertebrate model systems have suggested that Vangl and Pk may also inhibit signaling through the canonical Wnt/β-catenin p...

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Udgivet i:PLoS Genet
Main Authors: Mentink, Remco A., Rella, Lorenzo, Radaszkiewicz, Tomasz W., Gybel, Tomáš, Betist, Marco C., Bryja, Vitězslav, Korswagen, Hendrik C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307821/
https://ncbi.nlm.nih.gov/pubmed/30532125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007840
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