Evaluation of the antifibrotic potency by knocking down SPARC, CCR2 and SMAD3

BACKGROUND: The genes of SPARC, CCR2, and SMAD3 are implicated in orchestrating inflammatory response that leads to fibrosis in scleroderma and other fibrotic disorders. The aim of the studies is to evaluate synergistic anti-fibrotic potency of the siRNAs of these genes. METHODS: The efficacy of the...

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Библиографические подробности
Опубликовано в: :EBioMedicine
Главные авторы: Ding, Weifeng, Pu, Weilin, Jiang, Shuai, Ma, Yanyun, Liu, Qingmei, Wu, Wenyu, Chu, Haiyan, Zou, Hejian, Jin, Li, Wang, Jiucun, Zhou, Xiaodong
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2018
Предметы:
Research paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6306344/
https://ncbi.nlm.nih.gov/pubmed/30470612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.11.016
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