Evaluation of the antifibrotic potency by knocking down SPARC, CCR2 and SMAD3

BACKGROUND: The genes of SPARC, CCR2, and SMAD3 are implicated in orchestrating inflammatory response that leads to fibrosis in scleroderma and other fibrotic disorders. The aim of the studies is to evaluate synergistic anti-fibrotic potency of the siRNAs of these genes. METHODS: The efficacy of the...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Ding, Weifeng, Pu, Weilin, Jiang, Shuai, Ma, Yanyun, Liu, Qingmei, Wu, Wenyu, Chu, Haiyan, Zou, Hejian, Jin, Li, Wang, Jiucun, Zhou, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6306344/
https://ncbi.nlm.nih.gov/pubmed/30470612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.11.016
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