Evaluation of the antifibrotic potency by knocking down SPARC, CCR2 and SMAD3

BACKGROUND: The genes of SPARC, CCR2, and SMAD3 are implicated in orchestrating inflammatory response that leads to fibrosis in scleroderma and other fibrotic disorders. The aim of the studies is to evaluate synergistic anti-fibrotic potency of the siRNAs of these genes. METHODS: The efficacy of the...

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Bibliographic Details
Published in:EBioMedicine
Main Authors: Ding, Weifeng, Pu, Weilin, Jiang, Shuai, Ma, Yanyun, Liu, Qingmei, Wu, Wenyu, Chu, Haiyan, Zou, Hejian, Jin, Li, Wang, Jiucun, Zhou, Xiaodong
Format: Artigo
Language:Inglês
Published: Elsevier 2018
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Research paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6306344/
https://ncbi.nlm.nih.gov/pubmed/30470612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.11.016
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