Single-nucleus and single-cell transcriptomes compared in matched cortical cell types

Transcriptomic profiling of complex tissues by single-nucleus RNA-sequencing (snRNA-seq) affords some advantages over single-cell RNA-sequencing (scRNA-seq). snRNA-seq provides less biased cellular coverage, does not appear to suffer cell isolation-based transcriptional artifacts, and can be applied...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bakken, Trygve E., Hodge, Rebecca D., Miller, Jeremy A., Yao, Zizhen, Nguyen, Thuc Nghi, Aevermann, Brian, Barkan, Eliza, Bertagnolli, Darren, Casper, Tamara, Dee, Nick, Garren, Emma, Goldy, Jeff, Graybuck, Lucas T., Kroll, Matthew, Lasken, Roger S., Lathia, Kanan, Parry, Sheana, Rimorin, Christine, Scheuermann, Richard H., Schork, Nicholas J., Shehata, Soraya I., Tieu, Michael, Phillips, John W., Bernard, Amy, Smith, Kimberly A., Zeng, Hongkui, Lein, Ed S., Tasic, Bosiljka
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6306246/
https://ncbi.nlm.nih.gov/pubmed/30586455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0209648
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