Single-nucleus and single-cell transcriptomes compared in matched cortical cell types

Transcriptomic profiling of complex tissues by single-nucleus RNA-sequencing (snRNA-seq) affords some advantages over single-cell RNA-sequencing (scRNA-seq). snRNA-seq provides less biased cellular coverage, does not appear to suffer cell isolation-based transcriptional artifacts, and can be applied...

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Publicat a:PLoS One
Autors principals: Bakken, Trygve E., Hodge, Rebecca D., Miller, Jeremy A., Yao, Zizhen, Nguyen, Thuc Nghi, Aevermann, Brian, Barkan, Eliza, Bertagnolli, Darren, Casper, Tamara, Dee, Nick, Garren, Emma, Goldy, Jeff, Graybuck, Lucas T., Kroll, Matthew, Lasken, Roger S., Lathia, Kanan, Parry, Sheana, Rimorin, Christine, Scheuermann, Richard H., Schork, Nicholas J., Shehata, Soraya I., Tieu, Michael, Phillips, John W., Bernard, Amy, Smith, Kimberly A., Zeng, Hongkui, Lein, Ed S., Tasic, Bosiljka
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6306246/
https://ncbi.nlm.nih.gov/pubmed/30586455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0209648
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