Single-nucleus and single-cell transcriptomes compared in matched cortical cell types

Transcriptomic profiling of complex tissues by single-nucleus RNA-sequencing (snRNA-seq) affords some advantages over single-cell RNA-sequencing (scRNA-seq). snRNA-seq provides less biased cellular coverage, does not appear to suffer cell isolation-based transcriptional artifacts, and can be applied...

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Publié dans:PLoS One
Auteurs principaux: Bakken, Trygve E., Hodge, Rebecca D., Miller, Jeremy A., Yao, Zizhen, Nguyen, Thuc Nghi, Aevermann, Brian, Barkan, Eliza, Bertagnolli, Darren, Casper, Tamara, Dee, Nick, Garren, Emma, Goldy, Jeff, Graybuck, Lucas T., Kroll, Matthew, Lasken, Roger S., Lathia, Kanan, Parry, Sheana, Rimorin, Christine, Scheuermann, Richard H., Schork, Nicholas J., Shehata, Soraya I., Tieu, Michael, Phillips, John W., Bernard, Amy, Smith, Kimberly A., Zeng, Hongkui, Lein, Ed S., Tasic, Bosiljka
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6306246/
https://ncbi.nlm.nih.gov/pubmed/30586455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0209648
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