A Polygenic Risk Score Derived From Episodic Memory Weighted Genetic Variants Is Associated With Cognitive Decline in Preclinical Alzheimer’s Disease

Studies of Alzheimer’s disease risk-weighted polygenic risk scores (PRSs) for cognitive performance have reported inconsistent associations. This inconsistency is particularly evident when PRSs are assessed independent of APOE genotype. As such, the development and assessment of phenotype-specific w...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Porter, Tenielle, Burnham, Samantha C., Savage, Greg, Lim, Yen Ying, Maruff, Paul, Milicic, Lidija, Peretti, Madeline, Ames, David, Masters, Colin L., Martins, Ralph N., Rainey-Smith, Stephanie, Rowe, Christopher C., Salvado, Olivier, Taddei, Kevin, Groth, David, Verdile, Giuseppe, Villemagne, Victor L., Laws, Simon M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6305908/
https://ncbi.nlm.nih.gov/pubmed/30620773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2018.00423
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