Effects of APOE Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease

Polymorphic alleles in the apolipoprotein E (APOE) gene are the main genetic determinants of late-onset Alzheimer's disease (AD) risk. Individuals carrying the APOE E4 allele are at increased risk to develop AD compared to those carrying the more common E3 allele, whereas those carrying the E2...

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Pubblicato in:Front Mol Neurosci
Autori principali: Dai, Jingting, Johnson, Erik C. B., Dammer, Eric B., Duong, Duc M., Gearing, Marla, Lah, James J., Levey, Allan I., Wingo, Thomas S., Seyfried, Nicholas T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6305300/
https://ncbi.nlm.nih.gov/pubmed/30618606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00454
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