Effects of APOE Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease

Polymorphic alleles in the apolipoprotein E (APOE) gene are the main genetic determinants of late-onset Alzheimer's disease (AD) risk. Individuals carrying the APOE E4 allele are at increased risk to develop AD compared to those carrying the more common E3 allele, whereas those carrying the E2...

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Udgivet i:Front Mol Neurosci
Main Authors: Dai, Jingting, Johnson, Erik C. B., Dammer, Eric B., Duong, Duc M., Gearing, Marla, Lah, James J., Levey, Allan I., Wingo, Thomas S., Seyfried, Nicholas T.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6305300/
https://ncbi.nlm.nih.gov/pubmed/30618606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00454
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