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Using macropinocytosis for intracellular delivery of therapeutic nucleic acids to tumour cells

Nucleic acids are a rapidly emerging therapeutic modality with the potential to become the third major drug modality alongside antibodies and small molecules. Owing to the unfavourable physico-chemical characteristics of nucleic acids, such as large size and negative charge, intracellular delivery r...

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Bibliografiska uppgifter
I publikationen:Philos Trans R Soc Lond B Biol Sci
Huvudupphovsmän: Desai, Arpan S., Hunter, Morag R., Kapustin, Alexander N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Royal Society 2019
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6304741/
https://ncbi.nlm.nih.gov/pubmed/30967005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2018.0156
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