Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPSC reprogramming

BACKGROUND: Both human and mouse fibroblasts can be reprogrammed to pluripotency with Oct4, Sox2, Klf4, and c-Myc (OSKM) transcription factors. While both systems generate pluripotency, human reprogramming takes considerably longer than mouse. RESULTS: To assess additional similarities and differenc...

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Publicado en:BMC Genomics
Autores principales: Fu, Kai, Chronis, Constantinos, Soufi, Abdenour, Bonora, Giancarlo, Edwards, Miguel, Smale, Stephen T., Zaret, Kenneth S., Plath, Kathrin, Pellegrini, Matteo
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6303873/
https://ncbi.nlm.nih.gov/pubmed/30577748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-018-5326-1
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