Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming

Pioneer transcription factors (TFs) access silent chromatin and initiate cell fate changes, using diverse types of DNA binding domains (DBDs). FoxA, the paradigm pioneer TF, has a winged helix DBD that resembles linker histone and thereby binds its target sites on nucleosomes and in compacted chroma...

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Bibliografiske detaljer
Udgivet i:Cell
Main Authors: Soufi, Abdenour, Garcia, Meilin Fernandez, Jaroszewicz, Artur, Osman, Nebiyu, Pellegrini, Matteo, Zaret, Kenneth S.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409934/
https://ncbi.nlm.nih.gov/pubmed/25892221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.03.017
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