Centromere DNA Destabilizes H3 Nucleosomes to Promote CENP-A Deposition during the Cell Cycle

Active centromeres are defined by the presence of nucleosomes containing CENP-A, a histone H3 variant, which alone is sufficient to direct kinetochore assembly. Once assembled at a location, CENP-A chromatin and kinetochores are maintained at that location through a positive feedback loop where kine...

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Publicat a:Curr Biol
Autors principals: Shukla, Manu, Tong, Pin, White, Sharon A., Singh, Puneet P., Reid, Angus M., Catania, Sandra, Pidoux, Alison L., Allshire, Robin C.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6303189/
https://ncbi.nlm.nih.gov/pubmed/30503616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2018.10.049
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