The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface

Complement is a critical component of antimicrobial immunity. Various complement regulatory proteins prevent host cells from being attacked. Many pathogens have acquired the ability to sequester complement regulators from host plasma to evade complement attack. We describe here how Streptococcus pne...

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Publicat a:Infect Immun
Autors principals: Haleem, Kashif S., Ali, Youssif M., Yesilkaya, Hasan, Kohler, Thomas, Hammerschmidt, Sven, Andrew, Peter W., Schwaeble, Wilhelm J., Lynch, Nicholas J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Host Response and Inflammation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300637/
https://ncbi.nlm.nih.gov/pubmed/30323030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00742-18
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