Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model

Defects in the phosphoinositide 3-kinase (PI3K) pathway are shared characteristics in several brain disorders, including the inherited intellectual disability and autism spectrum disorder, fragile X syndrome (FXS). PI3K signaling therefore could serve as a therapeutic target for FXS and other brain...

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Bibliografske podrobnosti
izdano v:Neuropsychopharmacology
Main Authors: Gross, Christina, Banerjee, Anwesha, Tiwari, Durgesh, Longo, Francesco, White, Angela R., Allen, A. G., Schroeder-Carter, Lindsay M., Krzeski, Joseph C., Elsayed, Nada A., Puckett, Rosemary, Klann, Eric, Rivero, Ralph A., Gourley, Shannon L., Bassell, Gary J.
Format: Artigo
Jezik:Inglês
Izdano: Springer International Publishing 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300538/
https://ncbi.nlm.nih.gov/pubmed/30061744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0150-5
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