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Dysregulation and restoration of translational homeostasis in fragile X syndrome

Fragile X syndrome (FXS), the most-frequently inherited form of intellectual disability and the most-prevalent single-gene cause of autism, results from a lack of fragile X mental retardation protein (FMRP), an RNA-binding protein that acts, in most cases, to repress translation. Multiple pharmacolo...

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Detalhes bibliográficos
Publicado no:Nat Rev Neurosci
Main Authors: Richter, Joel D., Bassell, Gary J., Klann, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688896/
https://ncbi.nlm.nih.gov/pubmed/26350240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrn4001
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