Functional Genome-wide Screening Identifies Targets and Pathways Sensitizing Pancreatic Cancer Cells to Dasatinib

This study is an unbiased genomic screen to obtain functional targets for increased effectiveness of dasatinib in pancreatic cancer. Dasatinib, a multi-targeted tyrosine kinase inhibitor, is used in clinical trials for treatment of pancreatic cancer; however, intrinsic and acquired resistance often...

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Bibliographic Details
Published in:J Cancer
Main Authors: Chien, Wenwen, Sudo, Makoto, Ding, Ling-Wen, Sun, Qiao-Yang, Wuensche, Peer, Lee, Kian Leong, Hattori, Norimichi, Garg, Manoj, Xu, Liang, Zheng, Yun, Gery, Sigal, Wongphayak, Sarawut, Yang, Henry, Baloglu, Erkan, Shacham, Sharon, Kauffman, Michael, Mori, Seiichi, Koeffler, H. Phillip
Format: Artigo
Language:Inglês
Published: Ivyspring International Publisher 2018
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299388/
https://ncbi.nlm.nih.gov/pubmed/30588262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.25138
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