Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA

We report GSK3011724A (DG167) as a binary inhibitor of β-ketoacyl-ACP synthase (KasA) in Mycobacterium tuberculosis. Genetic and biochemical studies established KasA as the primary target. The X-ray crystal structure of the KasA-DG167 complex refined to 2.0-Å resolution revealed two interacting DG16...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Kumar, Pradeep, Capodagli, Glenn C., Awasthi, Divya, Shrestha, Riju, Maharaja, Karishma, Sukheja, Paridhi, Li, Shao-Gang, Inoyama, Daigo, Zimmerman, Matthew, Ho Liang, Hsin Pin, Sarathy, Jansy, Mina, Marizel, Rasic, George, Russo, Riccardo, Perryman, Alexander L., Richmann, Todd, Gupta, Aditi, Singleton, Eric, Verma, Sheetal, Husain, Seema, Soteropoulos, Patricia, Wang, Zhe, Morris, Roxanne, Porter, Gene, Agnihotri, Gautam, Salgame, Padmini, Ekins, Sean, Rhee, Kyu Y., Connell, Nancy, Dartois, Véronique, Neiditch, Matthew B., Freundlich, Joel S., Alland, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299220/
https://ncbi.nlm.nih.gov/pubmed/30563908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02101-17
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