Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA

We report GSK3011724A (DG167) as a binary inhibitor of β-ketoacyl-ACP synthase (KasA) in Mycobacterium tuberculosis. Genetic and biochemical studies established KasA as the primary target. The X-ray crystal structure of the KasA-DG167 complex refined to 2.0-Å resolution revealed two interacting DG16...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:mBio
Autori principali: Kumar, Pradeep, Capodagli, Glenn C., Awasthi, Divya, Shrestha, Riju, Maharaja, Karishma, Sukheja, Paridhi, Li, Shao-Gang, Inoyama, Daigo, Zimmerman, Matthew, Ho Liang, Hsin Pin, Sarathy, Jansy, Mina, Marizel, Rasic, George, Russo, Riccardo, Perryman, Alexander L., Richmann, Todd, Gupta, Aditi, Singleton, Eric, Verma, Sheetal, Husain, Seema, Soteropoulos, Patricia, Wang, Zhe, Morris, Roxanne, Porter, Gene, Agnihotri, Gautam, Salgame, Padmini, Ekins, Sean, Rhee, Kyu Y., Connell, Nancy, Dartois, Véronique, Neiditch, Matthew B., Freundlich, Joel S., Alland, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299220/
https://ncbi.nlm.nih.gov/pubmed/30563908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02101-17
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi