A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells

Active tuberculosis (TB) and latent Mycobacterium tuberculosis infection both require lengthy treatments to achieve durable cures. This problem has partly been attributable to the existence of nonreplicating M. tuberculosis “persisters” that are difficult to kill using conventional anti-TB treatment...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Sukheja, Paridhi, Kumar, Pradeep, Mittal, Nisha, Li, Shao-Gang, Singleton, Eric, Russo, Riccardo, Perryman, Alexander L., Shrestha, Riju, Awasthi, Divya, Husain, Seema, Soteropoulos, Patricia, Brukh, Roman, Connell, Nancy, Freundlich, Joel S., Alland, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312080/
https://ncbi.nlm.nih.gov/pubmed/28196957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02022-16
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