A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells

Active tuberculosis (TB) and latent Mycobacterium tuberculosis infection both require lengthy treatments to achieve durable cures. This problem has partly been attributable to the existence of nonreplicating M. tuberculosis “persisters” that are difficult to kill using conventional anti-TB treatment...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:mBio
Autori principali: Sukheja, Paridhi, Kumar, Pradeep, Mittal, Nisha, Li, Shao-Gang, Singleton, Eric, Russo, Riccardo, Perryman, Alexander L., Shrestha, Riju, Awasthi, Divya, Husain, Seema, Soteropoulos, Patricia, Brukh, Roman, Connell, Nancy, Freundlich, Joel S., Alland, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312080/
https://ncbi.nlm.nih.gov/pubmed/28196957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02022-16
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi