Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice

The gain-of-function MUC5B promoter variant rs35705950 is the dominant risk factor for developing idiopathic pulmonary fibrosis (IPF). Here we show in humans that MUC5B, a mucin thought to be restricted to conducting airways, is co-expressed with surfactant protein C (SFTPC) in type 2 alveolar epith...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hancock, Laura A., Hennessy, Corinne E., Solomon, George M., Dobrinskikh, Evgenia, Estrella, Alani, Hara, Naoko, Hill, David B., Kissner, William J., Markovetz, Matthew R., Grove Villalon, Diane E., Voss, Matthew E., Tearney, Guillermo J., Carroll, Kate S., Shi, Yunlong, Schwarz, Marvin I., Thelin, William R., Rowe, Steven M., Yang, Ivana V., Evans, Christopher M., Schwartz, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299094/
https://ncbi.nlm.nih.gov/pubmed/30560893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07768-9
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