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Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2
Mutations in the presenilin genes (PS1 and PS2) are a major cause of familial-Alzheimer’s disease (FAD). Presenilins regulate neurogenesis in the developing brain, with loss of PS1 inducing aberrant premature differentiation of neural progenitor cells, and additional loss of PS2 exacerbating this ef...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6299003/ https://ncbi.nlm.nih.gov/pubmed/30560948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36363-7 |
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