Sae2/CtIP prevents R-loop accumulation in eukaryotic cells

The Sae2/CtIP protein is required for efficient processing of DNA double-strand breaks that initiate homologous recombination in eukaryotic cells. Sae2/CtIP is also important for survival of single-stranded Top1-induced lesions and CtIP is known to associate directly with transcription-associated co...

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Vydáno v:eLife
Hlavní autoři: Makharashvili, Nodar, Arora, Sucheta, Yin, Yizhi, Fu, Qiong, Wen, Xuemei, Lee, Ji-Hoon, Kao, Chung-Hsuan, Leung, Justin WC, Miller, Kyle M, Paull, Tanya T
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2018
Témata:
Chromosomes and Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6296784/
https://ncbi.nlm.nih.gov/pubmed/30523780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.42733
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