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Tyrosine substitution of a conserved active‐site histidine residue activates Plasmodium falciparum peroxiredoxin 6

Peroxiredoxins efficiently remove hydroperoxides and peroxynitrite in pro‐ and eukaryotes. However, isoforms of one subfamily of peroxiredoxins, the so‐called Prx6‐type enzymes, usually have very low activities in standard peroxidase assays in vitro. In contrast to other peroxiredoxins, Prx6 homolog...

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Bibliografske podrobnosti
izdano v:Protein Sci
Main Authors: Feld, Kristina, Geissel, Fabian, Liedgens, Linda, Schumann, Robin, Specht, Sandra, Deponte, Marcel
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Inc. 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295898/
https://ncbi.nlm.nih.gov/pubmed/30056630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3490
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