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Tyrosine substitution of a conserved active‐site histidine residue activates Plasmodium falciparum peroxiredoxin 6

Peroxiredoxins efficiently remove hydroperoxides and peroxynitrite in pro‐ and eukaryotes. However, isoforms of one subfamily of peroxiredoxins, the so‐called Prx6‐type enzymes, usually have very low activities in standard peroxidase assays in vitro. In contrast to other peroxiredoxins, Prx6 homolog...

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Vydáno v:Protein Sci
Hlavní autoři: Feld, Kristina, Geissel, Fabian, Liedgens, Linda, Schumann, Robin, Specht, Sandra, Deponte, Marcel
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295898/
https://ncbi.nlm.nih.gov/pubmed/30056630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3490
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