Analogues of the Lignan Pinoresinol as Novel Lead Compounds for P-glycoprotein (P-gp) Inhibitors

[Image: see text] To find novel P-gp-inhibitors, a library of pregnane X receptor (PXR) ligands and the ZINC DrugsNow library were superimposed on the P-gp inhibitor (+)-pinoresinol (1) used as a query for a three-dimensional similarity search. After determining the TanimotoCombo index of similarity...

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Udgivet i:ACS Med Chem Lett
Main Authors: Laiolo, Jerónimo, Tomašič, Tihomir, Vera, D. Mariano A., González, María L., Lanza, Priscila A., Gancedo, Samanta N., Hodnik, Žiga, Peterlin Mašič, Lucija, Kikelj, Danijel, Carpinella, María C.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295845/
https://ncbi.nlm.nih.gov/pubmed/30613324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00324
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