Mechanism Underlying the Reversal of Drug Resistance in P-Glycoprotein-Expressing Leukemia Cells by Pinoresinol and the Study of a Derivative

P-glycoprotein (P-gp) is a membrane protein associated with multidrug resistance (MDR) due to its key role in mediating the traffic of chemotherapeutic drugs outside cancer cells, leading to a cellular response that hinders efforts toward successful therapy. With the aim of finding agents that circu...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Main Authors: González, María L., Vera, D. Mariano A., Laiolo, Jerónimo, Joray, Mariana B., Maccioni, Mariana, Palacios, Sara M., Molina, Gabriela, Lanza, Priscila A., Gancedo, Samanta, Rumjanek, Vivian, Carpinella, María C.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5403950/
https://ncbi.nlm.nih.gov/pubmed/28487651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00205
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