Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture

Tumorigenesis depends on intricate interactions between genetically altered tumor cells and their surrounding microenvironment. While oncogenic drivers in lung squamous carcinoma (LUSC) have been described, the role of stroma in modulating tissue architecture, particularly cell polarity, remains unc...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Chen, Shuang, Giannakou, Andreas, Wyman, Sarah, Gruzas, Janet, Golas, Jonathon, Zhong, Wenyan, Loreth, Christine, Sridharan, Latha, Yamin, Ting-Ting, Damelin, Marc, Geles, Kenneth G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294935/
https://ncbi.nlm.nih.gov/pubmed/30487219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803718115
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