Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture

Tumorigenesis depends on intricate interactions between genetically altered tumor cells and their surrounding microenvironment. While oncogenic drivers in lung squamous carcinoma (LUSC) have been described, the role of stroma in modulating tissue architecture, particularly cell polarity, remains unc...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chen, Shuang, Giannakou, Andreas, Wyman, Sarah, Gruzas, Janet, Golas, Jonathon, Zhong, Wenyan, Loreth, Christine, Sridharan, Latha, Yamin, Ting-Ting, Damelin, Marc, Geles, Kenneth G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294935/
https://ncbi.nlm.nih.gov/pubmed/30487219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803718115
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