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The FBXW2–MSX2–SOX2 axis regulates stem cell property and drug resistance of cancer cells
SOX2 is a key transcription factor that plays critical roles in maintaining stem cell property and conferring drug resistance. However, the underlying mechanisms by which SOX2 level is precisely regulated remain elusive. Here we report that MLN4924, also known as pevonedistat, a small-molecule inhib...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6789910/ https://ncbi.nlm.nih.gov/pubmed/31548378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905973116 |
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