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LSD1 destabilizes FBXW7 and abrogates FBXW7 functions independent of its demethylase activity
FBXW7 acts as a typical tumor suppressor, with loss-of-function alterations in human cancers, by promoting ubiquitylation and degradation of many oncoproteins. Lysine-specific demethylase 1 (LSD1) is a well-characterized histone demethylase. Whether LSD1 has demethylase-independent activity remains...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6589684/ https://ncbi.nlm.nih.gov/pubmed/31152129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902012116 |
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