Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility

Drug resistance is an obstacle to global malaria control, as evidenced by the recent emergence and rapid spread of delayed artemisinin (ART) clearance by mutant forms of the PfKelch13 protein in Southeast Asia. Identifying genetic determinants of ART resistance in African-derived parasites is import...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Demas, Allison R., Sharma, Aabha I., Wong, Wesley, Early, Angela M., Redmond, Seth, Bopp, Selina, Neafsey, Daniel E., Volkman, Sarah K., Hartl, Daniel L., Wirth, Dyann F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294886/
https://ncbi.nlm.nih.gov/pubmed/30420498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1812317115
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