Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility

Drug resistance is an obstacle to global malaria control, as evidenced by the recent emergence and rapid spread of delayed artemisinin (ART) clearance by mutant forms of the PfKelch13 protein in Southeast Asia. Identifying genetic determinants of ART resistance in African-derived parasites is import...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Demas, Allison R., Sharma, Aabha I., Wong, Wesley, Early, Angela M., Redmond, Seth, Bopp, Selina, Neafsey, Daniel E., Volkman, Sarah K., Hartl, Daniel L., Wirth, Dyann F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294886/
https://ncbi.nlm.nih.gov/pubmed/30420498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1812317115
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