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Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet

Mutations affecting the BSCL2 gene cause the most severe form of congenital generalised lipodystrophy. Affected individuals almost completely lack adipose tissue and suffer from severe diabetes and metabolic complications. Likewise, mice lacking Bscl2 in all tissues have dramatically reduced adipose...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Mcilroy, George D., Mitchell, Sharon E., Han, Weiping, Delibegović, Mirela, Rochford, Justin J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294754/
https://ncbi.nlm.nih.gov/pubmed/30552349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36078-9
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