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Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet

Mutations affecting the BSCL2 gene cause the most severe form of congenital generalised lipodystrophy. Affected individuals almost completely lack adipose tissue and suffer from severe diabetes and metabolic complications. Likewise, mice lacking Bscl2 in all tissues have dramatically reduced adipose...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Mcilroy, George D., Mitchell, Sharon E., Han, Weiping, Delibegović, Mirela, Rochford, Justin J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294754/
https://ncbi.nlm.nih.gov/pubmed/30552349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36078-9
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