Structural basis for recognition and repair of the 3′-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis

NExo is an enzyme from Neisseria meningitidis that is specialized in the removal of the 3′-phosphate and other 3′-lesions, which are potential blocks for DNA repair. NExo is a highly active DNA 3′-phosphatase, and although it is from the class II AP family it lacks AP endonuclease activity. In contr...

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Udgivet i:Nucleic Acids Res
Main Authors: Silhan, Jan, Zhao, Qiyuan, Boura, Evzen, Thomson, Hellen, Förster, Andreas, Tang, Christoph M, Freemont, Paul S, Baldwin, Geoff S
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Nucleic Acid Enzymes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294502/
https://ncbi.nlm.nih.gov/pubmed/30329088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky934
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