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Influence of pathway topology and functional class on the molecular evolution of human metabolic genes

Metabolic networks comprise thousands of enzymatic reactions functioning in a controlled manner and have been shaped by natural selection. Thanks to the genome data, the footprints of adaptive (positive) selection are detectable, and the strength of purifying selection can be measured. This has made...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Montanucci, Ludovica, Laayouni, Hafid, Dobon, Begoña, Keys, Kevin L., Bertranpetit, Jaume, Peretó, Juli
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294346/
https://ncbi.nlm.nih.gov/pubmed/30550546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0208782
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