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Influence of pathway topology and functional class on the molecular evolution of human metabolic genes

Metabolic networks comprise thousands of enzymatic reactions functioning in a controlled manner and have been shaped by natural selection. Thanks to the genome data, the footprints of adaptive (positive) selection are detectable, and the strength of purifying selection can be measured. This has made...

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Foilsithe in:PLoS One
Main Authors: Montanucci, Ludovica, Laayouni, Hafid, Dobon, Begoña, Keys, Kevin L., Bertranpetit, Jaume, Peretó, Juli
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294346/
https://ncbi.nlm.nih.gov/pubmed/30550546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0208782
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