Development of a Human iPSC Cardiomyocyte-Based Scoring System for Cardiac Hazard Identification in Early Drug Safety De-risking

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a promising cardiac safety platform, demonstrated by numerous validation studies using drugs with known cardiac adverse effects in humans. However, the challenge remains to implement hiPSC-CMs into cardiac de-risk...

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I publikationen:Stem Cell Reports
Huvudupphovsmän: Kopljar, Ivan, Lu, Hua Rong, Van Ammel, Karel, Otava, Martin, Tekle, Fetene, Teisman, Ard, Gallacher, David J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294263/
https://ncbi.nlm.nih.gov/pubmed/30540961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.11.007
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