Transcriptome 3′end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma

Diversification at the transcriptome 3′end is an important and evolutionarily conserved layer of gene regulation associated with differentiation and dedifferentiation processes. Here, we identify extensive transcriptome 3′end-alterations in neuroblastoma, a tumour entity with a paucity of recurrent...

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Publicat a:Nat Commun
Autors principals: Ogorodnikov, Anton, Levin, Michal, Tattikota, Surendra, Tokalov, Sergey, Hoque, Mainul, Scherzinger, Denise, Marini, Federico, Poetsch, Ansgar, Binder, Harald, Macher-Göppinger, Stephan, Probst, Hans Christian, Tian, Bin, Schaefer, Michael, Lackner, Karl J., Westermann, Frank, Danckwardt, Sven
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294251/
https://ncbi.nlm.nih.gov/pubmed/30552333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07580-5
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