Control of T(reg) cell homeostasis and immune equilibrium by Lkb1 in dendritic cells

To balance immunity and tolerance, the endogenous pool of Foxp3(+) regulatory T (T(reg)) cells is tightly controlled, but the underlying mechanisms of this control remain poorly understood. Here we show that the number of T(reg) cells is negatively regulated by the kinase Lkb1 in dendritic cells (DC...

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Publicado no:Nat Commun
Main Authors: Chen, Song, Fang, Lijun, Guo, Wei, Zhou, Yushan, Yu, Gang, Li, Wenwen, Dong, Kui, Liu, Jingru, Luo, Yuechen, Wang, Bing, Li, Zhonglong, Zhao, Chunxiao, Sun, Zhina, Shen, Yue, Leng, Qibing, Zhou, Dongming, Han, Zhongchao, Huang, Huifang, Ren, He, Xu, Guogang, Feng, Xiaoming
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294005/
https://ncbi.nlm.nih.gov/pubmed/30546010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07545-8
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