Critical Role of Lkb1 in the Maintenance of Alveolar Macrophage Self-Renewal and Immune Homeostasis

Alveolar macrophages (AMs) are pivotal for maintaining lung immune homeostasis. We demonstrated that deletion of liver kinase b1 (Lkb1) in CD11c(+) cells led to greatly reduced AM abundance in the lung due to the impaired self-renewal of AMs but not the impeded pre-AM differentiation. Mice with Lkb1...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Wang, Qianqian, Chen, Song, Li, Tengda, Yang, Qiongmei, Liu, Jingru, Tao, Yuan, Meng, Yuan, Chen, Jiadi, Feng, Xiaoming, Han, Zhongchao, Shi, Mingxia, Huang, Huifang, Han, Mingzhe, Jiang, Erlie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8100336/
https://ncbi.nlm.nih.gov/pubmed/33968022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.629281
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